Weighted multiple testing procedures for genomic studies
1 Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Geisel School of Medicine, Lebanon, NH, USA
2 Thayer School of Engineering, Dartmouth College, Hanover, NH, USA
3 Dartmouth-Hitchcock Medical Center, One Medical Center Dr., 883 Rubin Bldg, HB7927, Lebanon, NH 03756, USA
BioData Mining 2012, 5:4 doi:10.1186/1756-0381-5-4Published: 7 June 2012
With the rapid development of biological technology, measurement of thousands of genes or SNPs can be carried out simultaneously. Improved procedures for multiple hypothesis testing when the number of tests is very large are critical for interpreting genomic data. In this paper, we review recent developments on three distinct but closely related methods involving p-value weighting to improve statistical power while also controlling for the false discovery rate or the family wise error rate.