|
Contingency table underlying the guilt-by-association algorithm |
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| Disease Associated? |
Number of Connections |
% Disease-associated genes among interactors |
|
|
|
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| ≤ 75 |
> 75 |
||
|
|
|||
| Yes |
≤ 12 |
3,112 |
1,907 |
| > 12 |
481 |
651 |
|
|
|
|||
| No |
≤ 12 |
7,853 |
705 |
| > 12 |
229 |
112 |
|
|
Number of disease- and non-disease-associated genes by thresholds on number of connections and percentage of disease-associated genes among interactors. The thresholds are obtained from exploring disease-associated genes and correspond to the average number of connections (12) among disease-associated genes and the average proportion of disease-associated genes (75%) among their interactors. The 112 non-disease-associated genes (bottom right cell) form the basis of the newly reported disease-associated genes [see Additional file 2]. | |||
Reverter et al. BioData Mining 2008 1:8 doi:10.1186/1756-0381-1-8 |
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